Modern concept of Benign Breast Disorders and its Endocrinological Background

Mastalgia and generalised breast nodularity where a discrete lump cannot be felt called Aberration of Normal Development and Involution (ANDI) is the most common condition leading to breast related consultations. The author's work on this clinical syndrome over the last 3 decades has led to documentation of its natural history, epidemiological study of ANDI, development of objective scales for clinical assessment of breast pain and nodularity, its endocrinological aetiopathogenesis, response prediction of treatment in cyclical mastalgia, a randomized controlled trial of an indigenous selective estrogen response modulator - ormeloxifene and finally a meta-analysis of treatment for this condition. This turned a full wheel bridging gaps in the knowledge of this disorder and led us to evolve an effective, inexpensive treatment of mastalgia with least side effect. The work is dedicated to Professors LE Hughes, Robert E Mansel and Anurag Srivastava.