Key result
Steroids, particularly estradiol, and peptide hormones play a major role in controlling the expression of IGFBP-2 across a wide variety of tissues in vertebrates.
This review highlights the dominant role of estradiol and other steroids in regulating IGFBP-2 expression, suggesting potential molecular targets for malignant or metabolic diseases.
Should not yet change practice; leaves open IGFBP-2 as a target in hormone-linked disease pending human trials.
IGFBP-2 (1) has been described as a brain tumor oncogene (2) and is widely expressed in cancers from different origins (3-8). IGFBP-2 alone cannot cause malignant transformation, yet progression of brain tumors to higher grade (9) and also has been provided as a protective element in earlier stages of multistage colon carcinogenesis (10). Therefore, it is crucial to understand the factors that determine expression patterns of IGFBP-2 under normal and malignant conditions. The present review provides a comprehensive update of known factors that have an impact on expression of IGFBP-2.
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Hoeflich et al. (2014) conducted a review in IGFBP-2 expression. Steroids and peptide hormones was evaluated. Steroids, particularly estradiol, and peptide hormones play a major role in controlling the expression of IGFBP-2 across a wide variety of tissues in vertebrates.
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