Longitudinal assessment of the Unified Huntington's Disease Rating Scale (UHDRS) and UHDRS–For Advanced Patients (UHDRS‐FAP) in patients with late stage Huntington's disease

Jessica Y. Winder; Wilco P. Achterberg; Sarah L. Gardiner; R. A. C. Roos

doi:10.1111/ene.13889

December 21, 2018European Journal of Neurology

Longitudinal assessment of the Unified Huntington's Disease Rating Scale (UHDRS) and UHDRS–For Advanced Patients (UHDRS‐FAP) in patients with late stage Huntington's disease

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Key Points

To determine whether the UHDRS-For Advanced Patients (UHDRS-FAP) and standard UHDRS can detect longitudinal clinical changes in patients with late-stage Huntington's disease.
Evaluated 40 nursing home residents and day-care patients at baseline using the UHDRS, UHDRS-FAP, and Care Dependency Scale (CDS).
Repeated rating scale assessments after 6 months of follow-up in 29 remaining patients.
Calculated longitudinal changes using paired t-tests for the overall cohort and Wilcoxon signed-rank tests stratified by middle versus late disease stages.
Motor and cognitive scores on the UHDRS-FAP deteriorated significantly over 6 months, whereas motor and cognitive scores on the standard UHDRS showed no detectable change.
Two functional domains of the UHDRS and overall CDS scores demonstrated measurable functional decline over the 6-month period.
Behavioral scores improved significantly on both rating scales in late-stage patients, indicating that psychiatric manifestations diminish as the disease advances.

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Implication

Longitudinal study reveals that the UHDRS-FAP detects motor and cognitive decline in late-stage Huntington's disease, highlighting its utility for monitoring progression in care facilities.

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Winder et al. (2018) studied this question.

synapsesocial.com/papers/6a885283c0c64b7dddeb459f https://doi.org/10.1111/ene.13889

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Longitudinal assessment of the Unified Huntington's Disease Rating Scale (UHDRS) and UHDRS–For Advanced Patients (UHDRS‐FAP) in patients with late stage Huntington's disease

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Longitudinal assessment of the Unified Huntington's Disease Rating Scale (UHDRS) and UHDRS–For Advanced Patients (UHDRS‐FAP) in patients with late stage Huntington's disease

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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