Key result
Common genetic variations explained 8.7% of the variance in early neurological instability after acute ischemic stroke, identifying seven genome-wide significant loci including excitotoxic genes ADAM23 and GRIA1.
Why the study?
Early neurological instability after acute ischemic stroke significantly impacts long-term outcomes, but its underlying genetic architecture has not been investigated in genome-wide association studies.
Population
5,876 individuals with acute ischemic stroke from seven countries
Comparison
Common genetic variations associated with early neurological change
Design
Multi-ancestry meta-analysis
Follow-up
24h
Authors
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Does not yet alter acute stroke care; extends GWAS to acute neurological instability and supports functional validation of excitotoxicity loci.
Observational (n=5,876)
Yes
Effect estimate: 8.7% of variance explained
p-value: p=0.001
This multi-ancestry GWAS provides the first evidence that genetic variants related to excitotoxicity, including ADAM23 and GRIA1, contribute to early neurological instability after acute ischemic stroke.
Ibáñez et al. (2020) conducted an observational in Acute ischemic stroke (n=5,876). Common genetic variations was evaluated on Early neurological instability measured by the difference between NIHSS within 6 hours of stroke onset and NIHSS at 24 hours (ΔNIHSS) (8.7% of variance explained, p=0.001). Common genetic variations explained 8.7% of the variance in early neurological instability after acute ischemic stroke, identifying seven genome-wide significant loci including excitotoxic genes ADAM23 and GRIA1.
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