Key result
The genetic architecture of stroke risk significantly overlapped with that of type 2 diabetes (P=2.53×10−169), hypertension (P=3.93×10−04), and baseline stroke severity (P=0.03).
Why the study?
The genetic relationships between stroke risk, stroke severity, and early neurological changes are complex and not completely understood.
Observational
p-value: p=2.53×10−169
Stroke risk shares genetic architecture with T2DM, hypertension, and initial stroke severity, but early neurological change after stroke has a distinct genetic architecture.
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Supports shared genetic risk with T2DM and hypertension; leaves open distinct pathways for post-stroke recovery.
Ibáñez et al. (2019) conducted an observational in Stroke. The genetic architecture of stroke risk significantly overlapped with that of type 2 diabetes (P=2.53×10−169), hypertension (P=3.93×10−04), and baseline stroke severity (P=0.03).