Why the study?
Does N6-cyclohexyladenosine infusion alter glomerular vascular reactivity differently in AT1A receptor knockout mice compared to wild-type mice?
Does N6-cyclohexyladenosine infusion alter glomerular vascular reactivity differently in AT1A receptor knockout mice compared to wild-type mice?
AT1A receptor knockout mice exhibit a markedly reduced constrictor response to CHA, supporting a functional interaction between adenosine and angiotensin II in regulating afferent arteriolar tone.
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May indicate AT1A dependence of adenosine-induced afferent constriction in mice; leaves open translation to human glomerular regulation.
Traynor et al. (1998) studied this question.
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