Key result
The ACE DD genotype was not associated with an increased risk of coronary artery disease in the Iranian population, though significant differences were noted in ID (P<0.005) and II (P<0.05) genotypes.
Why the study?
Is the ACE gene DD genotype associated with an increased risk of coronary artery disease in the Iranian population?
Case-Control (n=487)
Is the ACE gene DD genotype associated with an increased risk of coronary artery disease in the Iranian population?
The ACE gene DD genotype is not associated with increased susceptibility to coronary artery disease in the Iranian population.
ACE DD genotype shows no CAD link in Iranians; leaves open validation of ID/II differences in larger prospective studies.
The coronary artery disease (CAD) is of the main causes of heart failure and there is evidence supporting the association of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and the susceptibility to CAD. Therefore, the relevance of ACE polymorphism for CAD was determined in the Iranian population. 487 age-matched individuals including 224 patients with >50% angiographically established coronary stenosis and 263 healthy subjects genotyped for ACE gene I/D polymorphism by a standard method. Paraclinical characteristics including lipid profile were also determined for both groups. While the systolic (p<0.0001) and diastolic (p<0.0001) blood pressure, serum cholesterol (p<0.005) and LDL-C (p<0.05) were significantly increased in CAD patients, our results show that there was no increased risk of CAD in association with DD genotype in Iranian population. Allele frequencies were also similar in both groups. Although, we found a significant difference in ID (p<0.005) and II (p<0.05) genotype between patients and healthy subjects. The present study showed that DD genotype does not increase the CAD susceptibility in the studied Iranian population and may not be as a risk factor. Therefore, further studies together with the other polymorphisms of ACE gene may be required to determine the relation between cardiovascular disease susceptibility and ACE genetic variations in Iranian population.
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Shafiee et al. (2010) conducted a case-control in Coronary artery disease (n=487). ACE gene DD genotype vs. Other ACE genotypes / Healthy subjects was evaluated on Risk of coronary artery disease. The ACE DD genotype was not associated with an increased risk of coronary artery disease in the Iranian population, though significant differences were noted in ID (P<0.005) and II (P<0.05) genotypes.
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