Cholesterol metabolism. 6. The fate of ingested cholesterol in the intact rat

The ether-extractable acids were separated into solid and liquid acid fractions, converted into methyl esters and fractionally distilled.The light petroleum-insoluble compounds were separated from the fractions.Analyses of the acids are given (Table 2): these show that the increases after cholesterol feeding occur in the solid, liquid and light petroleum-insoluble fractions.4. The methyl esters of the light petroleuminsoluble esters were chromatographed and gave a number of fractions, some of which are probably ketonic bile acids (Table 4).We are indebted to the Medical Research Council for a personal grant (to D.C.E.) and a grant for expenses.