What question did this study set out to answer?

To determine whether preserving versus ligating the inferior mesenteric artery during sigmoid colectomy for diverticular disease reduces the incidence of anastomotic leakage, overall morbidity, and 30-day postoperative mortality.

May 25, 2012Colorectal Disease

Is inferior mesenteric artery ligation during sigmoid colectomy for diverticular disease associated with increased anastomotic leakage? A meta‐analysis of randomized and non‐randomized clinical trials

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Authors

RCRoberto CirocchiUniversity of Perugia STStefano TrastulliAzienda Ospedaliera S.Maria EFEriberto FarinellaEast and North Hertfordshire NHS Trust

Discussion

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Implication

Meta-analysis demonstrates no significant reduction in anastomotic leakage with inferior mesenteric artery preservation during sigmoidectomy for diverticular disease, suggesting ligation remains safe.

Key Points

To determine whether preserving versus ligating the inferior mesenteric artery during sigmoid colectomy for diverticular disease reduces the incidence of anastomotic leakage, overall morbidity, and 30-day postoperative mortality.
Systematic review and meta-analysis of randomized and non-randomized clinical trials identified across electronic databases including Medline, Embase, and the Cochrane Central Register of Controlled Trials.
Identified four eligible clinical studies comprising a total pooled cohort of 400 patients undergoing sigmoidectomy for diverticular disease.
Anastomotic leakage occurred in 7.3% of patients with inferior mesenteric artery preservation compared to 11.3% with ligation, representing no statistically significant difference (OR 0.72, 95% CI 0.11–4.76; P=0.73).
Overall postoperative morbidity and 30-day mortality could not be compared through meta-analysis because these outcomes were reported in only a single included trial.

Cite This Study

Cirocchi et al. (2012) studied this question.

synapsesocial.com/papers/6a8855fdf9cabcdfeb4a6b4f https://doi.org/10.1111/j.1463-1318.2012.03103.x

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Is inferior mesenteric artery ligation during sigmoid colectomy for diverticular disease associated with increased anastomotic leakage? A meta‐analysis of randomized and non‐randomized clinical trials

Discussion

Member takes

Implication

Key Points

Cite This Study

Is inferior mesenteric artery ligation during sigmoid colectomy for diverticular disease associated with increased anastomotic leakage? A meta‐analysis of randomized and non‐randomized clinical trials

Discussion

Member takes

Implication

Key Points

Cite This Study

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