Why the study?
Does concurrent indomethacin and aspirin improve clinical indices of inflammation in patients with rheumatoid arthritis?
Population
20 patients with seropositive rheumatoid arthritis, mean age 56.2 years, mean disease duration 8.2 years.
Comparison
Indomethacin 100 mg/day and soluble aspirin 4… vs Indomethacin 100 mg/day plus placebo, and…
Design
RCT, Randomized using a Latin square matrix, Double-blind
Follow-up
14 days per treatment period
Authors
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No added anti-inflammatory benefit from indomethacin-aspirin combination in RA; confirms lack of synergy and supports monotherapy to limit adverse effects.
Does concurrent indomethacin and aspirin improve clinical indices of inflammation in patients with rheumatoid arthritis?
Concurrent administration of aspirin and indomethacin provides no significant clinical advantage over either drug alone in rheumatoid arthritis, but may increase side effects.
Brooks et al. (1975) studied this question.
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