Key result
Green tea extract (400 mg daily) decreased central augmentation index compared to placebo (-3.05% vs. 6.7%, p=0.04) over 12 weeks in normotensive patients with type 2 diabetes.
Why the study?
Type 2 diabetes mellitus is associated with premature atherosclerosis and arterial stiffening, while green tea polyphenols are considered cardioprotective substances.
Does green tea extract improve arterial stiffness, lipid profile, and sRAGE levels in normotensive patients with type 2 diabetes mellitus?
RCT (n=20)
Double-blind
randomised
Does green tea extract improve arterial stiffness, lipid profile, and sRAGE levels in normotensive patients with type 2 diabetes mellitus?
Absolute Event Rate: -3.05% vs 6.7%
p-value: p=.04
A daily dose of 400 mg of green tea extract for 12 weeks significantly improved arterial stiffness in normotensive patients with type 2 diabetes mellitus on standard therapy.
Supports adjunctive green tea extract for arterial stiffness in normotensive T2DM; extends evidence with RCT confirmation.
Type 2 diabetes mellitus (T2DM) is associated with premature atherosclerosis and arterial stiffening due to the accumulation of advanced glycation end-products in vessel walls. Green tea polyphenols are considered cardio-protective substances. In this randomised double-blind placebo-controlled trial (NCT02627898), we evaluated the effect of Green tea extract on arterial stiffness parameters, lipids, body composition and sRAGE levels. Twenty normotensive patients with T2DM treated with the standard therapy and statins, mean age 53.2 ± 9.4 years and mean BMI 30.1 ± 4.5 kg/m2, were randomised to receive a daily dose of 400 mg of green tea extract (polyphenols ≥90%, EGCG ≥45%) or placebo for 12 weeks. Compared to placebo, administration of green tea extract decreased central augmentation index (–3.05 ± 10.8% vs. 6.7 ± 0.1%, p = .04). These findings suggest that green tea extract could be used as an adjunct to the standard therapy to improve arterial stiffness in T2DM.
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Quezada-Fernández et al. (2019) conducted an RCT in Type 2 diabetes mellitus (n=20). Green tea extract vs. Placebo was evaluated on central augmentation index (p=.04). Green tea extract (400 mg daily) decreased central augmentation index compared to placebo (-3.05% vs. 6.7%, p=0.04) over 12 weeks in normotensive patients with type 2 diabetes.
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