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July 1, 1985Annals of Internal Medicine

Edrophonium: A Useful Provocative Test for Esophageal Chest Pain

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Why the study?

Does edrophonium provocation safely induce esophageal chest pain in patients without coronary artery disease?

Population

50 symptomatic patients without coronary artery disease and 25 age-matched controls; further testing in 125…

Comparison

Edrophonium vs Age-matched controls and placebo control

Design

Cohort

Authors

JRJoel E. RichterNorthwestern University

Discussion

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Implication

Edrophonium provocation may identify esophageal chest pain; hypothesis-generating and should not yet change practice.

Structured PICO

Does edrophonium provocation safely induce esophageal chest pain in patients without coronary artery disease?

P
Population
50 symptomatic patients without coronary artery disease and 25 age-matched controls; further testing in 125 unselected patients with chest pain referred to the laboratory.
I
Intervention
Edrophonium (80 micrograms/kg of body weight, intravenous bolus)
C
Comparator
Age-matched controls and placebo control
O
Outcome
Induction of esophageal chest painpatient reported

Edrophonium is a useful and safe provocative test for identifying esophageal causes of noncardiac chest pain.

Cite This Study

Joel E. Richter (1985) studied this question.

synapsesocial.com/papers/6a88585cceefe68dba4fcdbchttps://doi.org/10.7326/0003-4819-103-1-14
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Also Consider

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  1. 1Role of Autonomic Nervous System in the Pathogenesis of Prinzmetal's Variant Form of Angina1974 · 459 citations
  2. 2Use of Ergonovine to Identify Esophageal Spasm in Patients with Chest Pain1981 · 47 citations
  3. 3Coronary and peripheral arterial responses to ergometrine in patients susceptible to coronary and oesophageal spasm.1981 · 14 citations
  4. 4Prinzmetal’s Variant Angina1976 · 227 citations
  5. 5Oesophageal Function and Coronary Angiogram in Patients with Disabling Chest Pain1978 · 69 citations