Key result
Enalapril administered at a non-antihypertensive dose significantly prevented cardiac hypertrophy and improved parameters of cardiac mitochondrial dysfunction in spontaneously hypertensive rats.
Why the study?
Does enalapril at a non-antihypertensive dose improve cardiac mitochondrial function and tissue remodeling in spontaneously hypertensive rats?
Does enalapril at a non-antihypertensive dose improve cardiac mitochondrial function and tissue remodeling in spontaneously hypertensive rats?
Absolute Event Rate: 1.2% vs 1.6%
p-value: p=<0.01
Enalapril prevents cardiac hypertrophy and improves mitochondrial function in spontaneously hypertensive rats independently of its blood pressure-lowering effects.
Supports BP-independent mitochondrial protection by enalapril in rats; leaves open translation to human hypertension therapy.
Renal and cardiac benefits of renin-angiotensin system inhibition exceed blood pressure (BP) reduction and seem to involve mitochondrial function. It has been shown that RAS inhibition prevented mitochondrial dysfunction in spontaneously hypertensive rats (SHR) kidneys. Here, it is investigated whether a non-antihypertensive enalapril dose protects cardiac tissue and mitochondria function. Three-month-old SHR received water containing enalapril (10 mg/kg/day, SHR+Enal) or no additions (SHR-C) for 5 months. Wistar-Kyoto rats (WKY) were normotensive controls. At month 5, BP was similar in SHR+Enal and SHR-C. In SHR+Enal and WKY, heart weight and myocardial fibrosis were lower than in SHR-C. Matrix metalloprotease-2 activity was lower in SHR+Enal with respect to SHR-C and WKY. In SHR+Enal and WKY, NADH/cytochrome c oxidoreductase activity, eNOS protein and activity and mtNOS activity were higher and Mn-SOD activity was lower than in SHR-C. In summary, enalapril at a non-antihypertensive dose prevented cardiac hypertrophy and modifies parameters of cardiac mitochondrial dysfunction in SHR.
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Piotrkowski et al. (2009) studied Hypertension (n=19). Enalapril vs. Water with no additions was evaluated on Heart weight (p=<0.01). Enalapril administered at a non-antihypertensive dose significantly prevented cardiac hypertrophy and improved parameters of cardiac mitochondrial dysfunction in spontaneously hypertensive rats.
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