Key result
Nicorandil treatment adjunctive to reperfusion therapy reduced the incidence of TIMI flow grade ≤2 (RR 0.63) compared to control in patients with acute myocardial infarction.
Why the study?
Does nicorandil treatment adjunctive to reperfusion therapy improve functional outcomes in patients with acute myocardial infarction?
Population
Patients with acute myocardial infarction (AMI) undergoing reperfusion therapy (17 studies included)
Comparison
Nicorandil treatment adjunctive to reperfusion… vs Reperfusion therapy without nicorandil
Design
Meta-analysis
Authors
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Adjunctive nicorandil may enhance microvascular perfusion and LV recovery in AMI reperfusion; extends Level-1 support for routine use.
Meta-Analysis (n=1,982)
Does nicorandil treatment adjunctive to reperfusion therapy improve functional outcomes in patients with acute myocardial infarction?
Relative Risk: 0.63 (95% CI 0.44–0.91)
Absolute Event Rate: 8.7% vs 13.8%
p-value: p=0.01
Adjunctive nicorandil treatment during reperfusion therapy for AMI improves microvascular function and left ventricular functional recovery.
Iwakura et al. (2009) conducted a meta-analysis in Acute Myocardial Infarction (n=1,982). Nicorandil vs. Control was evaluated on Incidence of TIMI flow grade ≤2 after reperfusion (RR 0.63, 95% CI 0.44 to 0.91, p=0.01). Nicorandil treatment adjunctive to reperfusion therapy reduced the incidence of TIMI flow grade ≤2 (RR 0.63) compared to control in patients with acute myocardial infarction.
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