Patch testing with silver sulfadiazine cream

23 patients who had used silver sulfadiazine cream were patch tested. No reactions to the active principle occurred but 2 vehicle components, cetyl alcohol and propylene glycol, were positive. No sulfonamide-sensitive subject reacted to silver sulfadiazine. There is no evidence that silver sulfadiazine has a contact sensitizing potential or that it is contra-indicated for patients with a history of sulfonamide hypersensitivity.