Key result
Regular aspirin use at a mean daily dosage within 40 mg was associated with a decreased risk of incident Alzheimer's dementia in patients with type 2 diabetes mellitus (HR 0.51; 95% CI 0.27-0.97; P=0.041).
Why the study?
Does regular aspirin use reduce the incidence of dementia in patients with type 2 diabetes mellitus?
Population
Patients with type 2 diabetes mellitus from a nationwide, population-based cohort in Taiwan.
Design
Cohort
Follow-up
8 years
Authors
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Low-dose aspirin was associated with lower Alzheimer's risk in T2DM; hypothesis-generating and should not yet change practice.
Cohort
Yes
Does regular aspirin use reduce the incidence of dementia in patients with type 2 diabetes mellitus?
Hazard Ratio: 0.51 (95% CI 0.27–0.97)
p-value: p=0.041
Regular low-dose aspirin use (≤40 mg/day) may significantly reduce the risk of incident Alzheimer's dementia in patients with type 2 diabetes mellitus.
Chang et al. (2016) conducted a cohort in Type 2 diabetes mellitus. Regular aspirin use (mean daily dosage within 40 mg) was evaluated on Incident Alzheimer's dementia (HR 0.51, 95% CI 0.27-0.97, p=0.041). Regular aspirin use at a mean daily dosage within 40 mg was associated with a decreased risk of incident Alzheimer's dementia in patients with type 2 diabetes mellitus (HR 0.51; 95% CI 0.27-0.97; P=0.041).
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