Key result
Renal denervation lowered mean arterial pressure in early but not late stage diabetic kidney disease in rats, without improving glycemic control or renal function.
Why the study?
Contradictory findings have been reported regarding the effect of renal denervation on diabetic kidney disease progression in type 2 diabetes.
Does renal denervation improve mean arterial pressure, glycemic control, and renal function in type 2 diabetic nephropathy rats?
Does renal denervation improve mean arterial pressure, glycemic control, and renal function in type 2 diabetic nephropathy rats?
In a rat model of type 2 diabetic nephropathy, renal denervation lowered mean arterial pressure only in the early stages of the disease, without improving glycemic control or renal function.
RDNx stage-dependent effects in T2DN rats warrant caution on timing; leaves open human DKD translation and renal outcomes.
Diabetic kidney disease (DKD) is a major driver of morbidity and mortality worldwide. Although the FDA has recently approved renal denervation (RDNx) to treat hypertension, contradictory findings have been reported on the effect of RDNx on the progression of DKD in type 2 diabetes. Here, we used type 2 diabetic nephropathy (T2DN) rats, a well-established non-obese model that mimics key features in human DKD, to evaluate the effect of RDNx on the progression of DKD in the early and late stages of diabetic nephropathy. Results indicate that RDNx lowers mean arterial pressure in the early but not late stage of DKD without improving glycemic control or renal function, which may suggest that the effect of RDNx on type 2 diabetes is stage-dependent, emphasizing the importance of timing when considering RDNx as a potential treatment for DKD.
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Xu et al. (2025) studied Diabetic kidney disease. Renal denervation (RDNx) was evaluated on Mean arterial pressure, glycemic control, and renal function. Renal denervation lowered mean arterial pressure in early but not late stage diabetic kidney disease in rats, without improving glycemic control or renal function.
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