What question did this study set out to answer?

To evaluate the hypoglycemic mechanisms and active constituents of Lithocarpus polystachyus Rehd. leaf extract on hepatic glycogen synthesis in a mouse model of type 2 diabetes mellitus.

November 28, 2016PLoS ONEOpen Access

Leaf Extract from Lithocarpus polystachyus Rehd. Promote Glycogen Synthesis in T2DM Mice

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Authors

JWJinfei Wang YHYumin Huang KLKaixiang Li

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Overview

Experimental animal study demonstrates enhanced hepatic glycogen synthesis from Lithocarpus polystachyus extract in diabetic mice, indicating superior efficacy over isolated active compounds.

Key Points

To evaluate the hypoglycemic mechanisms and active constituents of Lithocarpus polystachyus Rehd. leaf extract on hepatic glycogen synthesis in a mouse model of type 2 diabetes mellitus.
Treated high-fat diet and streptozotocin-induced diabetic mice via oral gavage over four weeks with whole leaf extract, phloridzin, or trilobatin.
Measured physiological glucose flux, blood glucose and lipid panels, hepatic glycogen content, oxidative stress markers, and expression of glycometabolism-related genes.
All treatments reduced blood glucose over four weeks, but whole leaf extract demonstrated superior hypoglycemic efficacy compared to isolated trilobatin or phloridzin alone.
Leaf extract promoted hepatic glucose uptake and glycogen synthesis, attenuated oxidative stress and gluconeogenesis, upregulated GK, GLUT2, IR, and IRS, and downregulated G-6-P.

Cite This Study

Wang et al. (2016) studied this question.

synapsesocial.com/papers/6a88655a26735dbc5f76fef1 https://doi.org/10.1371/journal.pone.0166557

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November 28, 2016PLoS ONEOpen Access

Leaf Extract from Lithocarpus polystachyus Rehd. Promote Glycogen Synthesis in T2DM Mice

View Full Paper

Ask AI

Bookmark

Authors

JWJinfei Wang YHYumin Huang KLKaixiang Li

Discussion

Member takes

Overview

Experimental animal study demonstrates enhanced hepatic glycogen synthesis from Lithocarpus polystachyus extract in diabetic mice, indicating superior efficacy over isolated active compounds.

Key Points

To evaluate the hypoglycemic mechanisms and active constituents of Lithocarpus polystachyus Rehd. leaf extract on hepatic glycogen synthesis in a mouse model of type 2 diabetes mellitus.
Treated high-fat diet and streptozotocin-induced diabetic mice via oral gavage over four weeks with whole leaf extract, phloridzin, or trilobatin.
Measured physiological glucose flux, blood glucose and lipid panels, hepatic glycogen content, oxidative stress markers, and expression of glycometabolism-related genes.
All treatments reduced blood glucose over four weeks, but whole leaf extract demonstrated superior hypoglycemic efficacy compared to isolated trilobatin or phloridzin alone.
Leaf extract promoted hepatic glucose uptake and glycogen synthesis, attenuated oxidative stress and gluconeogenesis, upregulated GK, GLUT2, IR, and IRS, and downregulated G-6-P.

Cite This Study

Wang et al. (2016) studied this question.

synapsesocial.com/papers/6a88655a26735dbc5f76fef1 https://doi.org/10.1371/journal.pone.0166557

View Full Paper

Ask AI

Bookmark