Influence of Irradiation on Resistance to Infection

Infection is a very frequent lethal complication of wholebody x radiation in the LD/sub 50/ to LDi/sub 100/ range of dosage. Normal defenses against infection depend upon several factors, including the polymorphonuclear leucocytes, antibodies, bactericidal power of serum, and the retictiloendothelial system. The effects of x-radiation damage on these mechanisms are discussed. The beneficial effect of spleen homogenates and spleen shielding and previous treatment with endotoxins in radiation induced infections are discussed. Possible reaction mechanisms involved are considered. 57 references. (C.H.)