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Yoichi Hiraki*a, Yasuhiro Tsujib, Mikako Hiraikea, Nobuhiro Misumia, Kana Matsumotoc, Kunihiko Moritac, Hidetoshi Kamimurad & Yoshiharu Karubeda Department of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto, Kumamotob Department of Pharmacy, Sasebo Chuo Hospital, Sasebo, Nagasakic Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyotod Faculty of Pharmaceutical Sciences, Fukuoka University, Johnan-ku, Fukuoka, JapanCorrespondence: Y. Hiraki, Department of Pharmacy, National Hospital Organization Kumamoto Medical Center, 1-5 Ninomaru, Kumamoto, Kumamoto 860-0008, Japan. Tel: +81 96 353 6501. Fax: +81 96 325 2519. E-mail: hiraki@kumamoto2.hosp.go.jpAbstractWe evaluated the possible association between trough linezolid (LZD) concentrations and platelet counts using a dose–response curve with a logit model equation. We demonstrated that trough LZD concentrations correlated with platelet counts. A significant decrease in platelet count was observed in patients with trough LZD concentrations higher than 22.1 μg/ml.
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Hiraki et al. (2011) studied this question.
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