Association Between Inflammatory Components and Physical Function in the Health, Aging, and Body Composition Study: A Principal Component Analysis Approach
Population
1,269 older persons (subset of the Health, Aging, and Body Composition study)
Design
Cohort
Authors
Discussion
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Member takes
Implication
TNF-α-related inflammation links to reduced knee strength and performance in older adults; leaves open cytokine-specific interventions.
Structured PICO
P
Population
1,269 older persons (subset of the Health, Aging, and Body Composition study)
I
Intervention
Principal component analysis of eight inflammatory biomarkers (TNF-alpha, sTNFRI, sTNFRII, IL-6sR, IL-2sR, CRP, IL-6, plasminogen activator inhibitor-1)
O
Outcome
Associations between identified inflammatory components and measures of physical function (knee strength, physical performance battery score, 400-m walk time, grip strength, 20-m walking speed)surrogate
In older adults, distinct inflammatory components (TNF-alpha-related vs. CRP-related) have inconsistent and specific associations with different aspects of physical performance.
Cite This Study
Hsu et al. (2009) studied this question.