April 28, 2009Haemostasis

Protective Effects of Ticlopidine and Aspirin, Administered Alone and in Combination, on Thrombus Formation in Rat Cerebral Vessels

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Why the study?

Does the combination of ticlopidine and aspirin prevent thrombus formation in a rat cerebral vessel model?

Population

Rat animal model

Design

Preclinical

Follow-up

up to 3 days

Authors

YSYasuto SasakiKobe Gakuin University IIIzumi IshiiTokyo University of Agriculture and Technology JGJ. C. GiddingsCardiff University

Discussion

Member takes

Implication

May guide preclinical dual antiplatelet testing in thrombosis models; leaves open translation to human cerebrovascular disease.

Structured PICO

Does the combination of ticlopidine and aspirin prevent thrombus formation in a rat cerebral vessel model?

Population

Rat animal model

Intervention

Ticlopidine and d,l-lysine acetylsalicylate (L-ASA), administered alone and in combination, orally at concentrations from 100 mg/kg to 300 mg/kg

Outcome

Thrombus formation in cerebral blood vessels (arterioles and venules) induced by He-Ne laser methodsurrogate

The combination of ticlopidine and aspirin provides enhanced and prolonged antithrombotic effects in a rat model of cerebral thrombosis.

Cite This Study

Sasaki et al. (2009) studied this question.

synapsesocial.com/papers/6a8866b19fc8a8114e4a772f https://doi.org/10.1159/000217200

Topics

Dual antiplatelet therapy

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Protective Effects of Ticlopidine and Aspirin, Administered Alone and in Combination, on Thrombus Formation in Rat Cerebral Vessels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Protective Effects of Ticlopidine and Aspirin, Administered Alone and in Combination, on Thrombus Formation in Rat Cerebral Vessels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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