What question did this study set out to answer?

To evaluate the degree and duration of mosquitocidal effects, parity reductions, and Plasmodium sporozoite rate decreases following single ivermectin mass drug administrations across diverse West African transmission environments.

November 2, 2014Malaria JournalOpen Access

Evaluation of ivermectin mass drug administration for malaria transmission control across different West African environments

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Authors

HAHaoués AloutCentre de Coopération Internationale en Recherche Agronomique pour le Développement BKBenjamin J. KrajacichVector Oncology (United States)JMJacob I. MeyersAnn Arbor Center for Independent Living

Discussion

Member takes

Overview

Intervention study demonstrates reduced vector survival and parasite transmission in malaria-endemic villages, suggesting repeated ivermectin dosing can suppress transmission.

Key Points

To evaluate the degree and duration of mosquitocidal effects, parity reductions, and Plasmodium sporozoite rate decreases following single ivermectin mass drug administrations across diverse West African transmission environments.
Captured indoor-resting, blood-fed, and outdoor host-seeking Anopheles mosquitoes surrounding mass drug administration campaigns between 2008 and 2013 in Senegalese, Liberian, and Burkinabé villages.
Assessed mosquito mortality in indoor-collected vectors and evaluated parity status and Plasmodium sporozoite rates in host-seeking mosquitoes relative to post-treatment timing and environmental variables.
Anopheles gambiae survivorship decreased by 33.9% for one week following mass drug administration.
Parity rates were significantly reduced for more than two weeks following administration across all evaluated transmission settings.
Sporozoite rates were significantly reduced by >77% for two weeks post-treatment in treated villages during peak transmission seasons.

Cite This Study

Alout et al. (2014) studied this question.

synapsesocial.com/papers/6a886cbca082a64c2914ca3a https://doi.org/10.1186/1475-2875-13-417

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November 2, 2014Malaria JournalOpen Access

Evaluation of ivermectin mass drug administration for malaria transmission control across different West African environments

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Member takes

Overview

Intervention study demonstrates reduced vector survival and parasite transmission in malaria-endemic villages, suggesting repeated ivermectin dosing can suppress transmission.

Key Points

To evaluate the degree and duration of mosquitocidal effects, parity reductions, and Plasmodium sporozoite rate decreases following single ivermectin mass drug administrations across diverse West African transmission environments.
Captured indoor-resting, blood-fed, and outdoor host-seeking Anopheles mosquitoes surrounding mass drug administration campaigns between 2008 and 2013 in Senegalese, Liberian, and Burkinabé villages.
Assessed mosquito mortality in indoor-collected vectors and evaluated parity status and Plasmodium sporozoite rates in host-seeking mosquitoes relative to post-treatment timing and environmental variables.
Anopheles gambiae survivorship decreased by 33.9% for one week following mass drug administration.
Parity rates were significantly reduced for more than two weeks following administration across all evaluated transmission settings.
Sporozoite rates were significantly reduced by >77% for two weeks post-treatment in treated villages during peak transmission seasons.

Cite This Study

Alout et al. (2014) studied this question.

synapsesocial.com/papers/6a886cbca082a64c2914ca3a https://doi.org/10.1186/1475-2875-13-417

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