What question did this study set out to answer?

Assess respiratory mechanics, lung volumes, and breathing patterns to characterize pulmonary function abnormalities in children with cystic fibrosis.

August 1, 1959PEDIATRICS

Studies of Respiratory Physiology in Children

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Authors

CCC. D. CookUniversity of North Carolina at Chapel Hill PHP. J. HelliesenHarvard University LKLucas L. KulczyckiGeorgetown University

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Implication

Observational study shows impaired lung volumes and airway resistance in pediatric cystic fibrosis, highlighting respiratory mechanics as markers of clinical severity.

Key Points

Assess respiratory mechanics, lung volumes, and breathing patterns to characterize pulmonary function abnormalities in children with cystic fibrosis.
Measured tidal volume, respiratory rate, and lung volumes in 64 pediatric patients with cystic fibrosis of the pancreas.
Evaluated lung compliance and airway resistance in 42 patients, and performed serial lung volume assessments in 43 patients.
Residual volume was significantly increased in 46% and functional residual capacity in 21% of 61 patients without lobectomies, with 70% exhibiting an elevated RV/TLC ratio.
Vital capacity was significantly decreased in 34% of patients, lung resistance was increased in 35%, and lung compliance fell significantly in the most severely ill individuals.
Serial assessments showed no uniform trend across the group; however, 10% of surviving patients improved while 15% deteriorated.

Cite This Study

Cook et al. (1959) studied this question.

synapsesocial.com/papers/6a886d26c16cbaca05f4d599 https://doi.org/10.1542/peds.24.2.181

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Implication

Observational study shows impaired lung volumes and airway resistance in pediatric cystic fibrosis, highlighting respiratory mechanics as markers of clinical severity.

Studies of Respiratory Physiology in Children

Discussion

Member takes

Implication

Key Points

Cite This Study

Studies of Respiratory Physiology in Children

Discussion

Member takes

Implication

Key Points

Cite This Study

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