Analysis of a protein region involved in permeation and gating of the voltage‐gated Torpedo chloride channel ClC‐0.
Population
Torpedo electric organ chloride channel ClC-0 (in vitro model)
Comparison
Mutations in the region after putative… vs ClC-0 wild-type (WT) channels
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Cautions against clinical translation of ClC-0 findings; extends dual-gating models but leaves open human relevance.
Structured PICO
P
Population
Torpedo electric organ chloride channel ClC-0 (in vitro model)
I
Intervention
Mutations in the region after putative transmembrane domain D12 (including K519R)
C
Comparator
ClC-0 wild-type (WT) channels
O
Outcome
Effects on fast and slow gating, permeation properties, ion selectivity, and rectificationsurrogate
The region after transmembrane domain D12 in the ClC-0 chloride channel is involved in both fast and slow gating as well as permeation properties.
Cite This Study
Ludewig et al. (1997) studied this question.