Recipe for β‐Sheets: Foldamers Containing Amyloidogenic Peptide Sequences

This is the authors' abstract. We don't add key points for this paper.

This paper describes a new class of macrocyclic peptides that fold to form β‐sheet structures. These macrocyclic β‐sheets consist of a peptide sequence strand linked through two δ‐linked ornithine turn units to a peptide template strand containing a single N ‐methyl amino acid. The macrocycles were readily prepared from commercially available amino acids by solid‐phase peptide synthesis followed by solution‐phase cyclization. 1 H NMR spectroscopic studies showed that macrocycles containing amyloidgenic pentapeptide sequences from amyloid β‐peptide, tau protein, the B‐chain of insulin, and human prion protein fold to form β‐sheet structures.