Platelets expressing factor VIII can shield FVIII from immune detection and suppress anti-FVIII immune responses in a hemophilia A mouse model.
In this issue of Blood, Chen et al demonstrate that platelets expressing factor VIII (FVIII) shield FVIII from immune detection. In the naive FVIII null hemophilia A (HA) mouse, platelet-derived VIII prevents both a primary and memory anti-FVIII immune response, and together with total body irradiation, suppresses anti-FVIII immune response.
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Margaret V. Ragni (2016) studied this question.
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