December 1, 1989Journal of Biological ChemistryOpen Access

Transglutaminase-mediated Cross-linking of Fibrinogen by Human Umbilical Vein Endothelial Cells

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Population

Human umbilical vein endothelial cells (HUVECs)

Comparison

Incubation with 125I-labeled fibrinogen and… vs Control conditions without inhibitors

Design

Preclinical

Authors

JMJ MartinézMexican Social Security Institute ERElizabeth A. RichWalter Reed National Military Medical Center CBCarl BarsigianThomas Jefferson University

Discussion

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Implication

Animal data on endothelial fibrinogen cross-linking should not change practice; hypothesis-generating for transglutaminase in vascular thrombosis.

Structured PICO

Population

Human umbilical vein endothelial cells (HUVECs)

Intervention

Incubation with 125I-labeled fibrinogen and various inhibitors (e.g., monoclonal antibody 7E3, Arg-Gly-Asp-Ser tetrapeptide, transglutaminase inhibitors)

Comparator

Control conditions without inhibitors

Outcome

Binding and cross-linking of 125I-fibrinogen to endothelial cellssurrogate

Endothelial cells bind and cross-link fibrinogen via a cell-associated transglutaminase, a process partially inhibited by glycoprotein IIb-IIIa antibodies.

Cite This Study

Martinéz et al. (1989) studied this question.

synapsesocial.com/papers/6a886eabe8f756f5e660929c https://doi.org/10.1016/s0021-9258(19)47090-7

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Implication

Animal data on endothelial fibrinogen cross-linking should not change practice; hypothesis-generating for transglutaminase in vascular thrombosis.

Transglutaminase-mediated Cross-linking of Fibrinogen by Human Umbilical Vein Endothelial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transglutaminase-mediated Cross-linking of Fibrinogen by Human Umbilical Vein Endothelial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider