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December 28, 2018American Journal of Medical Genetics Part B Neuropsychiatric GeneticsOpen Access

Identified 77 genome-wide significant loci associated with body fat percentage and 174 with fat-free mass; genetic correlations of male and female body fat percentage with anorexia nervosa differed significantly (p < .0001, δ = −0.17).

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Why the study?

The reasons for the imbalanced sex ratio in anorexia nervosa remain unresolved despite its high genetic correlations with anthropometric and metabolic traits.

Population

155,961 healthy and medication-free individuals from the UK Biobank

Comparison

Sex-specific GWAS of BF% and FFM correlated with AN GWAS

Design

Sex-specific genome-wide association study and genetic correlation analysis

Authors

CHChristopher HübelHGHelena GasparJCJonathan R. I. Coleman

Discussion

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Overview

Sex-specific genetic correlations with anorexia may inform risk models; hypothesis-generating and requires causal validation before clinical use.

Structured PICO

P
Population
Healthy and medication-free subsample of the UK Biobank (n=155,961)
O
Outcome
Genetic correlations of body fat percentage (BF%) and fat-free mass (FFM) with anorexia nervosasurrogate

Sex-specific anthropometric and metabolic genetic factors related to body fat percentage may partially explain the female preponderance in anorexia nervosa.

Cite This Study

Hübel et al. (2018) studied this question.

synapsesocial.com/papers/6a8873fea082a64c2914cb4bhttps://doi.org/10.1002/ajmg.b.32709
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa2019 · 1,216 citations
  2. 2Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes2026 · 1 citations
  3. 3Unravelling sex differences in the genetic architecture of anxiety2026
  4. 4Sex-stratified GWAS of Body Fat Percentage after Adjusting for Testosterone and SHBG in the UK Biobank2023
  5. 5Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits2013 · 461 citations