Why the study?
Do potassium channels mediate the killing of target cells by human natural killer cells?
Do potassium channels mediate the killing of target cells by human natural killer cells?
Potassium channels in human natural killer cells are essential for the cell-mediated killing process, whereas the endogenous channel type in target cells is not critical.
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K+ channel blockade may impair NK cytotoxicity; hypothesis-generating for in vivo immunomodulation and should not yet change practice.
Schlichter et al. (1986) studied this question.
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