January 1, 1996Cell Communication & Adhesion

Soluble or Bound Laminin Elicit in Human Neuroblastoma Cells Short- or Long-Term Potentiation of a K+Inwardly Rectifying Current: Relevance to Neuritogenesis

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Population

SH-SY5Y human neuroblastoma cells

Comparison

Substrate-bound or soluble Laminin (bLN; sLN) vs Integrin-independent substrates (polylysine…

Design

Preclinical

Follow-up

up to 120 min

Authors

AAAnnarosa ArcangelUniversity of Florence LFLaura FaravelliNewron Pharmaceuticals (Italy)LBLaura BianchiUniversity of Miami

Discussion

Member takes

Implication

Hypothesis-generating in neuroblastoma models; leaves open any role for laminin-IIR signaling in cardiac cell fate.

Structured PICO

Population

SH-SY5Y human neuroblastoma cells

Intervention

Substrate-bound or soluble Laminin (bLN; sLN)

Comparator

Integrin-independent substrates (polylysine (PL); bovine serum albumin (BSA))

Outcome

Changes in the resting potential (VREST) and in the underlying ionic conductances (Inwardly Rectifying K+ current)surrogate

Integrin-mediated activation of an inwardly rectifying K+ current by laminin plays a crucial role in the commitment to neuritogenesis of neuroblastoma cells.

Cite This Study

Arcangel et al. (1996) studied this question.

synapsesocial.com/papers/6a8874c68c7e900eb714d492 https://doi.org/10.3109/15419069609010779

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Soluble or Bound Laminin Elicit in Human Neuroblastoma Cells Short- or Long-Term Potentiation of a K+Inwardly Rectifying Current: Relevance to Neuritogenesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Soluble or Bound Laminin Elicit in Human Neuroblastoma Cells Short- or Long-Term Potentiation of a K+Inwardly Rectifying Current: Relevance to Neuritogenesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider