August 1, 1962Proceedings of the National Academy of SciencesOpen Access

The Identification of the Ribosomal Rna Cistron by Sequence Complementarity, Ii. Saturation of and Competitive Interaction at the Rna Cistron

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Population

E. coli strains BB and A-155 (a uracilless derivative of B)

Comparison

Hybridization of ribosomal RNA with homologous… vs Nonribosomal RNA or heterologous DNA

Design

Preclinical

Authors

SYS. A. YankofskyUniversity of Southern California SSS. SpiegelmanRutgers, The State University of New Jersey

Discussion

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Implication

No immediate clinical implications in cardiology; leaves open rRNA gene mapping for future cardiovascular genomic research.

Structured PICO

Population

E. coli strains BB and A-155 (a uracilless derivative of B)

Intervention

Hybridization of ribosomal RNA (23S RNA) with homologous heat-denatured DNA

Comparator

Nonribosomal RNA (informational RNA) or heterologous DNA

Outcome

Formation of RNAase-resistant RNA-DNA complexes (saturation and competitive interaction)surrogate

This foundational basic science study demonstrates the presence of specific DNA sequences complementary to ribosomal RNA, showing saturation and competitive interaction.

Limitations

Exact value of 0.2% saturation level must not be taken too seriously until similar determinations are reported with other organisms
Only the 23S ribosomal component was employed

Cite This Study

Yankofsky et al. (1962) studied this question.

synapsesocial.com/papers/6a887553b98a632b5e4fe052 https://doi.org/10.1073/pnas.48.8.1466

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The Identification of the Ribosomal Rna Cistron by Sequence Complementarity, Ii. Saturation of and Competitive Interaction at the Rna Cistron

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

The Identification of the Ribosomal Rna Cistron by Sequence Complementarity, Ii. Saturation of and Competitive Interaction at the Rna Cistron

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider