December 22, 2008DiabetologiaOpen Access

The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study

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Why the study?

Does salsalate improve insulin action and glucose tolerance in obese non-diabetic patients?

Population

54 adults with BMI ≥30 kg/m2, non-diabetic by OGTT, non-smokers, and healthy except for obesity. 40…

Comparison

Salsalate 3 g/day orally for 7 days. vs Identical placebo orally for 7 days.

Design

RCT, Sequentially randomised in blocks by sex, Double-blind; participants and…

Follow-up

7 days

Authors

JKJ KoškaGeorgia Institute of Technology JBJoy C. BuntNational Institutes of Health AGAdeline GasserRegenerative NanoMedicine

Discussion

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Implication

Salsalate fails to improve peripheral insulin action after normalization; challenges direct sensitizing effects in obese non-diabetics.

Structured PICO

Does salsalate improve insulin action and glucose tolerance in obese non-diabetic patients?

Population

54 adults (18 to 45 years of age) with BMI ≥30 kg/m2, non-diabetic by OGTT, non-smokers, and healthy except for obesity. 40 participants were analyzed (salsalate n=22, placebo n=18).

Intervention

Salsalate 3 g/day orally (divided in two doses) for 7 days.

Comparator

Identical placebo orally (divided in two doses) for 7 days.

Outcome

Changes in insulin action assessed as rate of glucose disposal (Rd) by euglycaemic-hyperinsulinaemic clamp (insulin infusion rate 40 mU m-2 min-1) and glucose tolerance by 75 g OGTT.surrogate

Salsalate lowers fasting glucose in obese non-diabetic individuals, but this effect appears to be driven by increased systemic insulin concentrations rather than improved peripheral insulin action.

Cite This Study

Koška et al. (2008) studied this question.

synapsesocial.com/papers/6a887575d79ae02bd34e10f5 https://doi.org/10.1007/s00125-008-1239-x

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The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider