Expert review highlights diverse immunomodulatory roles of tumor necrosis factor receptors in immune cells, suggesting broad therapeutic opportunities for targeted agonists.
The receptors of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) fulfill crucial and manifold immunomodulatory functions and are involved in maintenance of tissue homeostasis and development. TNFRSF receptors (TNFRs) exhibit specific, though partially overlapping expression profiles, and elicit functional effects on the vast majority of immune cells at different stages of an immune response. TNFRs also crucially contribute to the communication between immune cells and immune cells with other cell types. The repertoire of immunomodulatory functions of TNFRs spans both adaptive as well as innate immunity. For example, TNFRs co-stimulate T-cells, engage antigen presenting cells (APCs) and regulate B-cell maturation. On the other hand, they contribute to tumor surveillance and are also involved in tissue regeneration and development.
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Obermajer et al. (2023) studied this question.
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