Why the study?
Inadequate myocardial protection and intraoperative myocardial injury are important and common complications in cardiac surgical procedures, prompting investigation into whether preoperative nicorandil reduces myocardial injury.
Does preoperative oral nicorandil reduce myocardial injury in patients undergoing open heart surgery?
Does preoperative oral nicorandil reduce myocardial injury in patients undergoing open heart surgery?
Preoperative administration of oral nicorandil significantly reduces myocardial injury, as measured by postoperative troponin levels, in patients undergoing open heart surgery.
Supports preoperative nicorandil to mitigate myocardial injury in open heart surgery; extends pharmacologic preconditioning evidence to this RCT setting.
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Shahzamani et al. (2024) studied this question.
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