Why the study?
Does prostaglandin E1 (PGE1) improve refractory pulmonary hypertension in a patient with mitral valve disease during surgery?
Does prostaglandin E1 (PGE1) improve refractory pulmonary hypertension in a patient with mitral valve disease during surgery?
Prostaglandin E1 may be an effective peri-operative treatment for refractory pulmonary hypertension resistant to glyceryl trinitrate during cardiac surgery.
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May support PGE1 consideration in refractory pulmonary hypertension during mitral surgery; hypothesis-generating and requires prospective trials.
Severe pulmonary hypertension (PH) can be a critical problem during and after cardiac surgery, since it increases right ventricular afterload resulting in decreased cardiac output. A case of pulmonary hypertension associated with mitral valve disease and resistant to glyceryl trinitrate therapy during surgery is reported. The case was treated successfully with prostaglandin E1 (PGE1), indicating that PGE1 can be used peri-operatively in a patient with refractory PH resistant to glyceryl trinitrate treatment.
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Mikawa et al. (1993) studied this question.
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