Why the study?
Does pentobarbital overload affect the myocardial redox state in open-chest rats?
Population
8 open-chest rats anesthetized with pentobarbital
Comparison
Slow IV infusion of 6% pentobarbital vs Baseline level prior to injection
Design
Preclinical
Follow-up
up to 50 min
Authors
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Pentobarbital may artifactually alter NADH signals in rat models; leaves open translation to other species or clinical monitoring.
Does pentobarbital overload affect the myocardial redox state in open-chest rats?
Pentobarbital overload significantly alters the myocardial energetic state, which can be continuously monitored in situ using NADH laser fluorimetry.
Renault et al. (1987) studied this question.
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