What does this research mean for the field?

In isolated rabbit hearts following coronary artery ligation, methylprednisolone and hyaluronidase significantly reduce the ischemic area and expand the oxygen-diffusion zone, whereas propranolol has no effect. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1982CirculationOpen Access

Pharmacologic modification of myocardial ischemia.

Q: What are the key findings of this study?

In rabbit hearts, methylprednisolone and hyaluronidase significantly reduced the ischemic area following coronary ligation (P<0.05 and P<0.01, respectively), whereas propranolol had no effect.

Q: What is the clinical evidence from this study?

Population: Myocardial ischemia (n=74). Intervention: Methylprednisolone, hyaluronidase, and propranolol vs. Control (crystalloid solution). Primary outcome: Ischemic area (p=<0.01).

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Key result

Methylprednisolone and hyaluronidase reduce ischemic area in rabbit hearts, whereas propranolol has no effect.

P<0.01
n=74

Why the study?

The value of methylprednisolone, hyaluronidase, and propranolol in reducing myocardial ischemic area in perfused rabbit hearts was examined.

Does methylprednisolone, hyaluronidase, or propranolol reduce the area of myocardial ischemia in a rabbit heart model?

Comparison

Methylprednisolone vs hyaluronidase vs propranolol vs control (crystalloid solution alone)

Design

Preclinical experimental study

Follow-up

60 minutes

Authors

LWLewis WetsteinKleijnen Systematic Reviews (United Kingdom)MSMichael B. SimsonUniversity of the Sciences PFP.D. FeldmanEli Lilly (United States)

Discussion

Member takes

Implication

Should not change clinical practice; leaves open translation of these rabbit findings to human infarction.

Structured PICO

Does methylprednisolone, hyaluronidase, or propranolol reduce the area of myocardial ischemia in a rabbit heart model?

Population

74 rabbit hearts subjected to coronary artery ligation to evaluate pharmacologic modification of myocardial ischemia over 60 minutes.

Intervention

Methylprednisolone (0.25 mg/ml), hyaluronidase (4 U/ml), or propranolol (1 microgram/ml) added to crystalloid solution

Comparator

Crystalloid solution alone (control)

Outcome

Area of myocardial ischemia evaluated by nicotinamide adenine dinucleotide autofluorescence photographysurrogate

Main Result

p-value: p=<0.01

Methylprednisolone and hyaluronidase, but not propranolol, significantly reduced the area of myocardial ischemia in an isolated rabbit heart model.

Cite This Study

Wetstein et al. (1982) studied Myocardial ischemia (n=74). Methylprednisolone, hyaluronidase, and propranolol vs. Control (crystalloid solution) was evaluated on Ischemic area (p=<0.01). In rabbit hearts, methylprednisolone and hyaluronidase significantly reduced the ischemic area following coronary ligation (P<0.05 and P<0.01, respectively), whereas propranolol had no effect.

synapsesocial.com/papers/6aaa0d6a0a88a9c60a481f1e https://doi.org/10.1161/01.cir.66.3.548

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Pharmacologic modification of myocardial ischemia.

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Pharmacologic modification of myocardial ischemia.

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider