Why the study?
Does propranolol reduce myocardial necrosis following temporary coronary artery occlusion in dogs?
Population
Open-chest dogs anesthetized with sodium pentobarbital undergoing 40 minutes of temporary circumflex…
Comparison
Propranolol administered 10 minutes prior to the… vs Untreated controls
Design
Preclinical
Follow-up
2-5 days
Authors
Loading...
May attenuate necrosis in canine ischemia-reperfusion; leaves open translation to human myocardial infarction.
Does propranolol reduce myocardial necrosis following temporary coronary artery occlusion in dogs?
Pre-treatment with intravenous propranolol significantly reduces myocardial necrosis following temporary coronary artery occlusion and reperfusion in a canine model.
Reimer et al. (1973) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: