Why the study?
Does the Arg53His polymorphism in the human kallikrein gene reduce urinary kallikrein activity and associate with hypertension?
Population
A normotensive group and two independent hypertensive groups (Caucasian subjects)
Comparison
Presence of human kallikrein gene polymorphisms vs Subjects without the specific polymorphisms
Design
Cross-sectional
Authors
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Arg53His heterozygosity links to reduced kallikrein activity without hypertension association; leaves open its role in renal and vascular disease.
Does the Arg53His polymorphism in the human kallikrein gene reduce urinary kallikrein activity and associate with hypertension?
The identification of the Arg53His loss-of-function polymorphism in the human kallikrein gene explains genetically reduced kallikrein activity, providing a basis for further analysis of the kallikrein-kinin system in renal and vascular diseases.
Slim et al. (2002) studied this question.
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