Why the study?
Does tissue kallikrein deficiency cause cardiovascular abnormalities in mice?
Population
Tissue kallikrein-deficient mice
Design
Preclinical
Follow-up
early in adulthood
Authors
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Tissue kallikrein deficiency may impair cardiac and vascular function independently of blood pressure; leaves open its relevance to human cardiovascular disease.
Does tissue kallikrein deficiency cause cardiovascular abnormalities in mice?
Tissue kallikrein is the main kinin-generating enzyme in vivo and is necessary for normal cardiac and arterial function in mice.
Meneton et al. (2001) studied this question.
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