Key result
Tissue kallikrein protects against oxidative damage in cardiovascular and renal diseases and ischemic stroke independently of blood pressure reduction in experimental animal models.
Why the study?
Does the tissue kallikrein-kinin system protect against cardiovascular and renal diseases and ischemic stroke?
Population
Experimental animal models and humans with hypertension, cardiovascular and renal diseases
Design
Review
Authors
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Hypothesis-generating in animal models; leaves open human trials to test tissue kallikrein-kinin system as therapeutic target.
Does the tissue kallikrein-kinin system protect against cardiovascular and renal diseases and ischemic stroke?
The tissue kallikrein-kinin system represents a potential novel therapeutic target for the prevention and treatment of heart failure, renal disease, and stroke.
Chao et al. (2006) conducted a review in Cardiovascular and renal diseases, ischemic stroke. Tissue kallikrein/kinin system was evaluated. Tissue kallikrein protects against oxidative damage in cardiovascular and renal diseases and ischemic stroke independently of blood pressure reduction in experimental animal models.
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