November 22, 2023University Heart JournalOpen Access

Rate of Cardiotoxicity in Childhood Acute Lymphoblastic Leukemia Treated with Daunorubicin Using Echocardiography and Troponin I

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Why the study?

Childhood ALL survivors face increased lifelong cardiovascular risk mainly from daunorubicin, prompting this study to detect the rate of daunorubicin-induced cardiotoxicity during induction chemotherapy.

Population

40 newly diagnosed ALL patients aged 1 to17.9 years receiving daunorubicin during induction

Comparison

Before vs after completion of induction phase chemotherapy

Design

Prospective observational study

Authors

TSTania SultanaBangladesh Agricultural University TCTapas ChowdhuryIndira Gandhi Agricultural University FIFarzana IslamBangladesh University

Discussion

Member takes

Implication

Supports echocardiographic monitoring during daunorubicin induction in childhood ALL; leaves open troponin utility and long-term outcomes.

Structured PICO

Population

40 newly diagnosed patients with acute lymphoblastic leukemia (ALL) aged 1 to 17.9 years (mean age 10.15, 60% male) receiving daunorubicin during induction phase chemotherapy at a single center in Bangladesh. Key inclusion: baseline LVEF ≥60%.

Intervention

Daunorubicin during induction phase chemotherapy (UK ALL 2003 protocol regimen-B)

Outcome

Rate of daunorubicin-induced cardiotoxicity (defined as reduction of LVEF >5% to <55% with symptoms of HF or asymptomatic reduction of LVEF >10% to <55%) after completion of induction periodsurrogate

Daunorubicin induction chemotherapy in childhood ALL is associated with a 20% rate of early cardiotoxicity as evidenced by LVEF reduction, highlighting the need for routine echocardiographic monitoring.

Limitations

3D or strain echocardiography, Doppler myocardial imaging (DMI) and Cardiac MRI were not done
Biomarkers to detect cardiotoxicity like Troponin T and NT-pro BNP were not measured

Cite This Study

Sultana et al. (2023) studied this question.

synapsesocial.com/papers/6a8879a0d79ae02bd34e12ce https://doi.org/10.3329/uhj.v19i1.69821

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Implication

Supports echocardiographic monitoring during daunorubicin induction in childhood ALL; leaves open troponin utility and long-term outcomes.

Rate of Cardiotoxicity in Childhood Acute Lymphoblastic Leukemia Treated with Daunorubicin Using Echocardiography and Troponin I

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Rate of Cardiotoxicity in Childhood Acute Lymphoblastic Leukemia Treated with Daunorubicin Using Echocardiography and Troponin I

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider