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January 1, 1999Arthritis & Rheumatism

Relationship of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover: Analyses of synovial fluid from patients with osteoarthritis

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Population

54 patients with osteoarthritis (OA)

Design

Cross-sectional

Authors

NINaoki IshiguroTITakayasu ItoTohoku UniversityHIHideo ItoYamagata University

Discussion

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Implication

Synovial fluid TIMP-cartilage marker correlations may aid OA phenotyping; leaves open whether these changes predict progression or response to therapy.

Structured PICO

P
Population
54 patients with osteoarthritis (OA)
O
Outcome
Relationship between matrix metalloproteinases (MMPs), their inhibitors, and the turnover of matrix molecules in articular cartilagesurrogate

In patients with osteoarthritis, synovial fluid concentrations of TIMPs are linked to the synthesis of specific cartilage molecules, and late-stage disease is characterized by a measurable loss of cartilage structural components.

Cite This Study

Ishiguro et al. (1999) studied this question.

synapsesocial.com/papers/6a8879f5f9cabcdfeb4a6f63https://doi.org/10.1002/1529-0131(199901)42:1<129::aid-anr16>3.0.co;2-4
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Age-related changes in the structure of the proteoglycan subunits from human articular cartilage.1980 · 339 citations
  2. 2Matrix metalloproteinases and their inhibitors in connective tissue remodeling1991 · 3,303 citations
  3. 3The Glycosaminoglycans of Normal and Arthritic Cartilage1971 · 204 citations
  4. 4Quantitation of chondroitin 4—sulfate and chondroitin 6—sulfate in pathologic joint fluid1992 · 155 citations