Haptoglobin determines the site of Hb uptake when the Hb was administered intravenously: Hb-Hp and free Hb distribute into the liver and kidneys, respectively. There exists a certain limit in the liver to incorporate Hb-Hp suggesting the presence of some mechanism on liver cell membrane to recognize or incorporate the molecule.
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Akaiwa et al. (1976) studied this question.
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