June 15, 2003Journal of NeuroscienceOpen Access

Angiotensin II Stimulates Spinally Projecting Paraventricular Neurons through Presynaptic Disinhibition

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

Spinally projecting Paraventricular nucleus (PVN) neurons from rats, labeled by a retrograde fluorescence tracer injected into the thoracic spinal cord

Intervention

Application of 0.1-5 microm Angiotensin II (Ang II)

Comparator

Baseline conditions and co-administration with antagonists (losartan, PD123319, or bicuculline)

Outcome

Amplitude and frequency of evoked and miniature GABAergic IPSCs and glutamatergic EPSCs, and firing rate of PVN neuronssurrogate

Angiotensin II excites spinally projecting PVN neurons by attenuating GABAergic synaptic inputs through the activation of presynaptic AT1 receptors.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not support clinical changes in AT1 blocker use; leaves open presynaptic AT1 modulation of PVN GABA inputs for translational research.

Cite This Study

Li et al. (2003) studied this question.

synapsesocial.com/papers/6a88ebdb3aa2d8278f75ff7f https://doi.org/10.1523/jneurosci.23-12-05041.2003

View Full Paper

Ask AI

Bookmark

Implication

Does not support clinical changes in AT1 blocker use; leaves open presynaptic AT1 modulation of PVN GABA inputs for translational research.

Angiotensin II Stimulates Spinally Projecting Paraventricular Neurons through Presynaptic Disinhibition

Structured PICO

Discussion

Implication

Cite This Study

Angiotensin II Stimulates Spinally Projecting Paraventricular Neurons through Presynaptic Disinhibition

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider