Why the study?
Does PARP inhibitor PJ34 improve endothelial function in aging Wistar rats?
Does PARP inhibitor PJ34 improve endothelial function in aging Wistar rats?
Inhibition of PARP with PJ34 restores endothelial function in aging rats, suggesting intraendothelial PARP activation contributes to age-related endothelial dysfunction.
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Does not support clinical use; hypothesis-generating for PARP inhibition in human endothelial aging.
Pacher et al. (2002) studied this question.
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