March 1, 2002Journal of Biological ChemistryOpen Access

Basal and Stimulated Protein S-Nitrosylation in Multiple Cell Types and Tissues

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Population

Cultured endothelial cells, aortic rings, cultured macrophages, PC12 cells, and human lung tissue

Design

Preclinical

Authors

AGAndrew J. GowRutgers, The State University of New Jersey QCQiping ChenEast China Jiaotong University DHDouglas T. HessUniversity School

Discussion

Member takes

Implication

Hypothesis-generating for NOS-coupled S-nitrosylation in cardiovascular tissues; leaves open human translation and therapeutic relevance.

Structured PICO

Population

Cultured endothelial cells, aortic rings, cultured macrophages, PC12 cells, and human lung tissue

Intervention

Stimulation of nitric-oxide synthase (NOS) activity via Ca(2+), cytokines, or nerve growth factor

Outcome

Protein S-nitrosylation (SNO-protein immunoreactivity)surrogate

This study provides immunohistochemical evidence that protein S-nitrosylation is a ubiquitous NO-derived post-translational modification coupled to NOS activity across multiple cell types.

Cite This Study

Gow et al. (2002) studied this question.

synapsesocial.com/papers/6a88edfb37d2918d2e125d27 https://doi.org/10.1074/jbc.c100746200

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Basal and Stimulated Protein S-Nitrosylation in Multiple Cell Types and Tissues

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Basal and Stimulated Protein S-Nitrosylation in Multiple Cell Types and Tissues

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider