January 14, 1999Nephron Experimental Nephrology

Inducible Nitric Oxide Synthase Induction in Thy 1 Glomerulonephritis Is Complement and Reactive Oxygen Species Dependent

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Population

Rat model of Thy 1 glomerulonephritis induced by intravenous anti-Thy 1 antibody

Comparison

N-acetyl-cysteine and soluble complement… vs Untreated nephritic rats/glomeruli

Design

Preclinical

Follow-up

30 min to 24 h after induction

Authors

KMK. MosleyUniversity of Memphis SWSimon N. WaddingtonUniversity College London HEHatim EbrahimSt George's Hospital

Discussion

Member takes

Implication

Hypothesis-generating for NAC in experimental glomerulonephritis; human trials needed before any clinical consideration.

Structured PICO

Population

Rat model of Thy 1 glomerulonephritis induced by intravenous anti-Thy 1 antibody

Intervention

N-acetyl-cysteine (NAC) (i.p. 1,000 mg/kg, 1 h prior to anti-Thy 1) and soluble complement receptor 1 (sCR1)

Comparator

Untreated nephritic rats/glomeruli

Outcome

Glomerular nitrite (NO-2) synthesis, iNOS mRNA expression, and reactive oxygen species (ROS) chemiluminescencesurrogate

In a rat model of Thy 1 glomerulonephritis, inhibition of ROS by NAC or complement by sCR1 suppresses iNOS induction and subsequent injury, indicating complement-dependent ROS generation is the initiating event.

Cite This Study

Mosley et al. (1999) studied this question.

synapsesocial.com/papers/6a88f5eccd9902a7ca1268b4 https://doi.org/10.1159/000020581

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January 14, 1999Nephron Experimental Nephrology

Inducible Nitric Oxide Synthase Induction in Thy 1 Glomerulonephritis Is Complement and Reactive Oxygen Species Dependent

View Full Paper

Ask AI

Bookmark

Population

Rat model of Thy 1 glomerulonephritis induced by intravenous anti-Thy 1 antibody

Comparison

N-acetyl-cysteine and soluble complement… vs Untreated nephritic rats/glomeruli

Design

Preclinical

Follow-up

30 min to 24 h after induction

Authors

KMK. MosleyUniversity of Memphis SWSimon N. WaddingtonUniversity College London HEHatim EbrahimSt George's Hospital

Discussion

Member takes

Implication

Hypothesis-generating for NAC in experimental glomerulonephritis; human trials needed before any clinical consideration.

Structured PICO

Population

Rat model of Thy 1 glomerulonephritis induced by intravenous anti-Thy 1 antibody

Intervention

N-acetyl-cysteine (NAC) (i.p. 1,000 mg/kg, 1 h prior to anti-Thy 1) and soluble complement receptor 1 (sCR1)

Comparator

Untreated nephritic rats/glomeruli

Outcome

Glomerular nitrite (NO-2) synthesis, iNOS mRNA expression, and reactive oxygen species (ROS) chemiluminescencesurrogate

Cite This Study

Mosley et al. (1999) studied this question.

synapsesocial.com/papers/6a88f5eccd9902a7ca1268b4 https://doi.org/10.1159/000020581

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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