Irisin as a Novel Biomarker of Subclinical Atherosclerosis in Severe Obesity

Figures

• 

  Figure 1. Irisin concentration in participants with SO with/without plaques before and after BS. Results are represented in a boxplot showing the median and first to the third quartiles, with whiskers showing the 5th and 95th percentiles. Points below and above the whiskers are drawn as individual points. Two-way ANOVA (group and time of follow-up) was performed with the Bonferroni post-hoc test. n = 61 subjects; n = 30 with plaque, and n = 31 without plaque. Statistical differences were considered significant when p < 0.05. Symbol (o) denotes differences in the post-test vs. SO for the same group. Symbol (*) denotes differences in the post-test vs. with-plaque group for the same time. One or two of either symbols denote p < 0.05 or p < 0.01, respectively. Abbreviations: 6M, 6 months after surgery; 12M, 12 months after surgery; BS, bariatric surgery; ns, non-significant; SO, severe obesity at 1 month before bariatric surgery.

• 

  Figure 2. Association of irisin levels with BMI in participants with SO with/without atheromatous plaques before and after BS. Results were obtained after Pearson’s test and expressed as the Pearson’s coefficient (r). n = 61 subjects. In gray, subjects with plaque; in white, subjects without plaque. Abbreviations: BMI, body mass index.

• 

  Figure 3. Goodness of irisin level prediction in participants with SO before BS. Quantified using ROC curve analysis with the AUC and its 95% CI (n = 61 subjects). The dotted line is the reference line (AUC = 0.5). Abbreviations: AUC, area under the ROC curve; CI, confidence interval; ROC, receiver operating characteristic.